Syrian Rue, also known as Peganum harmala and classified as an MAO Inhibitor, is a perennial shrub native to the Middle East and Central Asia. It has a long history of use in traditional medicine and religious rituals, particularly among the indigenous peoples of these regions. The plant contains a group of alkaloids, including harmine, harmaline, and tetrahydroharmine, which have psychoactive properties and can induce hallucinations and altered states of consciousness. In addition to its cultural and spiritual uses, Syrian Rue has also been studied for its potential medicinal properties, including its ability to inhibit monoamine oxidase, an enzyme that breaks down neurotransmitters such as serotonin and dopamine, and its antioxidant and anti-inflammatory effects. Additionally, Syrian Rue has been found to possess antioxidant properties, which may help protect the body against oxidative stress and reduce inflammation. Other potential benefits of Syrian Rue include improving gastrointestinal health and alleviating pain, stress, and anxiety.